Assays and Services

CAMM Assays and Services for Pharmacodynamic Analysis in Bacterial Diseases

RS ratioTM assay

A novel molecular readout of the effect of drugs and drug combinations on bacterial cellular processes.  By providing information that complements traditional culture-based enumeration, the RS ratio is transforming in vitro, in preclinical and human studies.   


CAMM provides RS ratio collection kits and performs RS ratio profiling in a quality-assured workflow in the CAMM Molecular Core.


Contact chantal.underkofler@microbialmetrics.org to order collection kits and for assay services.


IRDM

Informed Regimen Design Metrics- a multi-element system of bacterial phenotyping to comprehensively evaluate the effect of drugs on the physiologic state and cellular process of M. tuberculosis in vitro


MARS

Mtb Amplicon RNA Sequencing – targeted method of quantifying the M. tuberculosis transcriptome at low bacterial abundance in animal treatment models


STAR-MAP

Single-Tubercle Analysis of rRNA Microenvironmental Atlas of Populations. Probes M. tuberculosis rRNA in whole-tissue to quantitatively and spatially define bacterial populations by ribosomal synthesis with single-bacillus resolution. The platform also supports multiplexed analysis with host protein and nucleic acid targets.  


Knowledge Integration 

Systems pharmacology and PK/DP modeling harness established and novel PD markers to maximize insight


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