Assays and Services

CAMM Assays and Services for Pharmacodynamic Analysis in Bacterial Diseases

RS ratioTM

A unique molecular measure of ongoing  rRNA synthesis in bacterial populations for use in vitro, in preclinical and human studies


IRDM

Informed Design Regimen Metrics- a multi-element system of bacterial phenotyping to comprehensively evaluate the effect of drugs on the physiologic state and cellular process of M. tuberculosis in vitro


MARS

Mtb Amplicon RNA Sequencing – targeted method of quantifying the M. tuberculosis transcriptome at low bacterial abundance in animal treatment models


STAR-MAP

Single-Tubercle Analysis of rRNA Microenvironmental Atlas of Populations. Probes M. tuberculosis rRNA in whole-tissue to quantitatively and spatially define bacterial populations by ribosomal synthesis with single-bacillus resolution. The platform also supports multiplexed analysis with host protein and nucleic acid targets.  


Knowledge Integration 

Systems pharmacology and PK/DP modeling harness established and novel PD markers to maximize insight